SOFTWARE

Laboratory GitHub Site: https://github.com/AltschulerWu-Lab

PUBLICATIONS

  1. Bao F, Deng Y, Wan S, Wang B, Dai Q, Altschuler SJ, Wu LF. Characterizing tissue composition through combined analysis of single-cell morphologies and transcriptional states. 
    View in: bioRxiv 2020.

     

  2. Kochanowski K, Sander T, Link H, Chang J, Altschuler SJ, Wu LF. Dissecting the impact of metabolic environment on three common cancer cell phenotypes. 
    View in: bioRxiv 2020.

     

  3. Sanman LE, Chen IW, Bieber JM, Steri V, Hann B, Wu LF, Altschuler SJ. Transit-amplifying cells coordinate changes in intestinal epithelial cell-type composition. 
    View in: bioRxiv 2020.

     

  4. Morinishi L, Kochanowski K, Levine RL,Wu LF, Altschuler SJ. Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Cell Systems. 2020 July;16(4):311-314. DOI:https://doi.org/10.1016/j.cels.2020.06.003.
    See also Editor's Choice (Science Translational Medicine)
    View in: PubMed.

     

  5. Sanman LE, Chen IW, Bieber JM, Thorne CA, Wu LF, Altschuler SJ. Generation and Quantitative Imaging of Enteroid Monolayers. Methods in Molecular Biology, volume 2171: Intestinal Stem Cells Methods and Protocols. 2020;2171:99-113. doi: 10.1007/978-1-0716-0747-3_6; PMID: 32705637.
    View in: Pubmed.
    Full Book: Intestinal Stem Cells, Methods and Protocols.

     

  6. Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF. A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. Scientific Data. 2019 October 31. ;6(1):253. doi: 10.1038/s41597-019-0225-0.

    View in: PubMed.
     

  7. Hsu CH, Altschuler SJ, Wu LF. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019 Jun 7. pii: S0092-8674(19)30612-9. doi: 10.1016/j.cell.2019.05.041.
    See also Preview (Cell), Editor's Choice (Science Translational Medicine), News & Views (Nature).
    View in: PubMed.

     

  8. Deng Y., Bao F., Dai Q., Wu LF, Altschuler SJ. Scalable analysis of cell-type composition from single-cell transcriptomics using deep recurrent learning. 2019 Apr;16(4):311-314. doi: 10.1038/s41592-019-0353-7. Epub 2019 Mar 18.
    View in: PubMed.

     

  9. Sebag AS, Heinrich L, Schoenauer M, Sebag M, Wu LF, Altschuler SJ Multi-domain adversarial learning.ICLR’19 - Seventh annual International Conference on Learning Representations, May 2019, New Orleans, United States. 2019, Proc. ICLR. 2019 
    View in: Preprint 
    Code: GitHub

     

  10. Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW; Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia. Jul 6;20(8):826-837. doi: 10.1016/j.neo.2018.06.002. 
    View in: PubMed

     

  11. Kochanowski K, Morinishi L, Altschuler SJ, Wu LF; Drug persistence - From antibiotics to cancer therapies. Current Opinion in Systems Biology. 2018 Aug; 10:1-8.
     

  12. Thurley K, Wu LF, Altschuler SJ; Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Systems. 2018 March 7. DOI: https://doi.org/10.1016/j.cels.2018.01.016. 
    View in: bioRxiv and PubMed

     

  13. Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ; Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization.Developmental Cell. 2018 Feb 26. pii: S1534-5807(18)30059-5. doi: 10.1016/j.devcel.2018.01.024. 
    Accompanying Preview
    View in: PubMed

     

  14. Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Sep 4. doi: 10.1038/nmeth.4427. PMID: 28869755 
    View in: PubMed

     

  15. Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler SJ, Wu LF.  Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 Jun 1;77(11):3070-3081. PMID: 28377453
    View in: PubMed

     

  16. Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH.  Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. J Sci Signal. 2016 Dec 13;9(458):ra122. 
    View in: PubMed

     

  17. Coster AD, Thorne CA, Wu LF, Altschuler SJ.  Examining crosstalk among Transforming Growth Factor β, Bone Morphogen Protein, and Wnt pathways. J Biol Chem. 2016 Nov 28. pii: jbc.M116.759654. 
    View in: PubMed

     

  18. Deng Y, Altschuler SJ, Wu LF.  PHOCOS: inferring multi-feature phenotypic crosstalk networks.Bioinformatics (special issue in ISMB 2016 proceedings). 2016 Jun 15;32(12):i44-i51. doi: 10.1093/bioinformatics/btw251. PMID: 27307643. 
    View in: PubMed

     

  19. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 Jun 9;14(6):e1002474. doi: 10.1371/journal.pbio.1002474. eCollection 2016 Jun. 
    View in: PubMed

     

  20. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19;7:10690. doi: 10.1038/ncomms10690. PMCID: PMC4762880. Accompanying news and views
    View in: PubMed

     

  21. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nature Biotechnology. 2015 Dec 14;doi: 10.1038/nbt.3419. 
    Accompanying article in the news.
    View in: PubMed

     

  22. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 2;162(1):120-133. doi: 10.1016/j.cell.2015.05.055. Epub 2015 Jun 25. 
    Accompanying Cell preview article and in the news. 
    View in: PubMed

     

  23. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler SJ, Wu LF, Kortholt A, Weiner OD.  Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 1;26(9):1629-39. doi: 10.1091/mbc.E14-07-1197. Epub 2015 Mar 4. 
    View in: PubMed

     

  24. Steininger RJ 3rd, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ.  On comparing heterogeneity across biomarkers. Cytometry part A (special issue on systems microscopy). 2014 Nov 25. doi: 10.1002/cyto.a.22599.
    View in: PubMed

     

  25. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ.  GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2014 Nov 17. doi: 10.1038/nchembio.1690. 
    View in: PubMed

     

  26. Agi E, Langen M, Altschuler SJ, Wu LF, Zimmermann T, Hiesinger PR. The Evolution and Development of Neural Superposition. J Neurogenet. 2014 Jul 8; 1-17. 
    View in: PubMed

     

  27. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 May 29; 11(6):602. View in: PubMed
     

  28. Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler SJ. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014; (85). 
    View in: PubMed

     

  29. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. 
    View in: PubMed

     

  30. Zhang ER, Wu LF, Altschuler SJ. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. 
    View in: PubMed

     

  31. Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F. The Zoo of Solitons for Curve Shortening in ℝn.Nonlinearity. 2013; 26(5):1189-1226
    Videos.

     

  32. Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu LF. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jul; 9(7):634-5. 
    View in: PubMed

     

  33. Rajaram S, Pavie B, Wu LF, Altschuler SJ. PhenoRipper: software for rapidly profiling microscopy images.  Nat Methods. 2012 Jul; 9(7):635-7. 
    View in: PubMed

     

  34. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83
    View in: PubMed

     

  35. Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15.
    View in: PubMed

     

  36. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. 
    View in: PubMed

     

  37. Jilkine A, Angenent SB, Wu LF,
    Altschuler SJ. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Computational Biol. 2011 Nov; 7(11):e1002271. 
    View in: PubMed

     

  38. Altschuler SJ, Wu LF. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. 
    View in: PubMed

     

  39. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. 
    View in: PubMed

     

  40. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. On identifying information from image-based spatial polarity phenotypes in neutrophils. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 1; 14-17:1029-1032. 
    View in: PubMed

     

  41. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 2; 187(3):375-84
    View in: PubMed

     

  42. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. 
    View in: PubMed

     

  43. Artyukhin AB, Wu LF, Altschuler SJ. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. 
    View in: PubMed

     

  44. Slack MD, Martinez ED, Wu LF, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19306-11. View in: PubMed
     

  45. Altschuler SJ, Angenent SB, Wang Y, Wu LF. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9.
    View in: PubMed

     

  46. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. 
    View in: PubMed

     

  47. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. 
    View in: PubMed

     

  48. Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. 
    View in: PubMed

     

  49. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. 
    View in: PubMed

     

  50. Loo, L.H., Wu, L., Altschuler, S.J., 2006; 251-54. Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
     

  51. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. 
    View in: PubMed

     

  52. Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. 
    View in: PubMed

     

  53. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. 
    View in: PubMed

     

  54. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. 
    View in: PubMed

     

  55. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. View in: PubMed
     

  56. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. 
    View in: PubMed

     

  57. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7. 
    View in: PubMed

     

  58. Acero, A., Altschuler S.J., Wu L.F. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. Proceedings of the ICSLP. 2000.
     

  59. Altschuler, S.J., Wu, L.F. On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
     

  60. Ridgeway, G., Altschuler, S.J. Clustering finite discrete markov chains. Proceedings of the Section on Physical and Engineering Sciences. 1998; 228-229.
     

  61. Altschuler, S.J., Kim, W. Proceedings of the ICSR5. Generating Signal Processing Software. 1998.
     

  62. Altschuler, S.J., Angenet, S., Giga, Y. Mean curvature flow through singularities for surfaces of rotation. Journal of Geometric Analysis. 1995; 5(3):293-358.
     

  63. Altschuler, S.J. A geometric heat flow for one-forms on three dimensional manifolds. Illinois Journal of Mathematics. 1995; 39(1):98-118.
     

  64. Altschuler, S.J., Wu, L.F. Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
     

  65. Wu, L.F. The Ricci Flow on complete R2. Comm. in Analysis and Geometry. 1993; 1:439-472.
     

  66. Wu, L.F. A new result for the porous medium equation on R2 derived from the Ricci flow. Bulletin of the American Mathematical Society. 1993; 28:90-94.
     

  67. Altschuler, S.J., Wu, L.F. Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
     

  68. Altschuler, S.J., Grayson, M. Shortening space curves and flow through singularities. Journal of Differential Geometry. 1992; 35(2):283-298.
     

  69. Altschuler, S.J. Singularities for the curve shortening flow for space curves. Journal of Differential Geometry. 1991; 34(2):491-514.
     

  70. Wu, L.F. The Ricci Flow on 2-orbifolds with positive curvature. Journal of Differential Geometry. 1991; 33:575-596.
     

  71. Chow, B., Wu, L.F. The Ricci Flow on compact 2-orbifolds with curvature negative somewhere. Communications on Pure and Applied Mathematics. 1991; 44:275-286.

SELECT SPATIAL PATTERNING PULBICATIONS

  1. Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ; Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Developmental Cell. 2018 Feb 26. pii: S1534-5807(18)30059-5. doi: 10.1016/j.devcel.2018.01.024. 
    Accompanying Preview. View in: PubMed

  2. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 2;162(1):120-133. doi: 10.1016/j.cell.2015.05.055. Epub 2015 Jun 25. 
    Accompanying Cell preview article and in the news. View in: PubMed

  3. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. 
    View in: PubMed

  4. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. 
    View in: PubMed

  5. Jilkine A, Angenent SB, Wu LF,Altschuler SJ. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Computational Biol. 2011 Nov; 7(11):e1002271. 
    View in: PubMed

  6. Altschuler SJ, Angenent SB, Wang Y, Wu LF. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9.View in: PubMed

  7. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. 
    View in: PubMed

  8. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. 
    View in: PubMed

 

SELECT DRUG DISCOVERY PUBLICATIONS

  1. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nature Biotechnology. 2015 Dec 14;doi: 10.1038/nbt.3419. 
    Accompanying article in the news. View in: PubMed

  2. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ.  GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2014 Nov 17. doi:10.1038/nchembio.1690. 
    View in: PubMed

  3. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 May 29; 11(6):602. 
    View in: PubMed

  4. Rajaram S, Pavie B, Wu LF, Altschuler SJ. PhenoRipper: software for rapidly profiling microscopy images.  Nat Methods. 2012 Jul; 9(7):635-7. 
    View in: PubMed

  5. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. View in: PubMed

  6. Slack MD, Martinez ED, Wu LF, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19306-11. 
    View in: PubMed

  7. Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. 
    View in: PubMed

  8. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. 
    View in: PubMed

 

SELECT CELLULAR HETEROGENEITY PUBLICATIONS

  1. Morinishi L, Kochanowski K, Levine RL,Wu LF, Altschuler SJ. Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Cell Systems. 2020 July;16(4):311-314. DOI:https://doi.org/10.1016/j.cels.2020.06.003.
    View in: PubMed.

  2. Hsu CH, Altschuler SJ, Wu LF. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019 Jun 7. pii: S0092-8674(19)30612-9. doi: 10.1016/j.cell.2019.05.041.See also Preview (Cell), Editor's Choice (Science Translational Medicine), News & Views (Nature).
    View in: PubMed.

  3. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19;7:10690. doi: 10.1038/ncomms10690. PMCID: PMC4762880. Accompanying news and views. 
    View in: PubMed

  4. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. 
    View in: PubMed

  5. Altschuler SJ, Wu LF. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. 
    View in: PubMed

  6. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. 
    View in: PubMed

  7. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 2; 187(3):375-84. 
    View in: PubMed

  8. Slack MD, Martinez ED, Wu LF, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19306-11. 
    View in: PubMed

 

©2020 by Wu and Altschuler Lab.