We seek to understand design principles of biological systems and diseases.
We study mechanisms underlying how biological networks rewire during disease progression. Ongoing areas of focus are: cancer drug resistance, neurodegeneration and ischemia.
We combine intravital imaging, novel organoid systems, computer vision and modeling to understand how complex, patterned tissues develop and are maintained.
We are developing rapid, scalable and effective ways to identify novel drugs and drug targets.
We develop computational strategies to predict small molecule function from diverse data sources, including high-throughput microscopy and genomics information.
We combine systems-biology and high-throughput approaches for discovering early drug leads for cancer, neurodegeneration and ischemia.
We are grateful for all the generous support we have received over the years, including current funding from: NIH, DARPA, Project ALS, The Chan Zuckerberg Initiative, The Mark Foundation for Cancer Research, The UCSF Program for Breakthrough in Biomedical Research (PBBR), and generous gifts from the Squires and Berkelhammer families.