We seek to understand design principles of biological systems and diseases.
We combine intravital imaging, novel organoid systems, computer vision and modeling to understand how complex, patterned tissues develop and are maintained.
We study mechanisms underlying how biological networks rewire during disease progression. Ongoing areas of focus are: cancer drug resistance, neurodegeneration and ischemia.
We are developing rapid, scalable and effective ways to identify novel drugs and drug targets.
We develop computational strategies to predict small molecule function from diverse data sources, including high-throughput microscopy and genomics information.
We combine systems-biology and high-throughput approaches for discovering early drug leads for cancer and neurodegeneration.
We are grateful for all the generous support we have received over the years, including current funding from: NIH, DARPA, ProjectALS, The Chan Zuckerberg Initiative, The UC Multicampus Research Program and Initiatives, and the UCSF Program for Breakthrough in Biomedical Research (PBBR).