1. Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler SJ, Wu LF.  Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 Jun 1;77(11):3070-3081. PMID: 28377453
    View in: PubMed
  2. Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH.  Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. J Sci Signal. 2016 Dec 13;9(458):ra122.
    View in: PubMed
  3. Coster AD, Thorne CA, Wu LF, Altschuler SJ.  Examining crosstalk among Transforming Growth Factor β, Bone Morphogen Protein, and Wnt pathways. J Biol Chem. 2016 Nov 28. pii: jbc.M116.759654.
    View in: PubMed
  4. Deng Y, Altschuler SJ, Wu LF.  PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics (special issue on ISMB 2016 proceedings). 2016 Jun 15;32(12):i44-i51. doi: 10.1093/bioinformatics/btw251. PMID: 27307643.
    View in: PubMed
  5. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 Jun 9;14(6):e1002474. doi: 10.1371/journal.pbio.1002474. eCollection 2016 Jun.
    View in: PubMed
  6. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19;7:10690. doi: 10.1038/ncomms10690.
    Accompanying news and views.
    View in: PubMed
  7. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nature Biotechnology. 2015 Dec 14;doi: 10.1038/nbt.3419.
    Accompanying article in the news.
    View in: PubMed
  8. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 2;162(1):120-133. doi: 10.1016/j.cell.2015.05.055. Epub 2015 Jun 25.
    Accompanying Cell preview article and in the news.
    View in: PubMed
  9. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler SJ, Wu LF, Kortholt A, Weiner OD.  Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 1;26(9):1629-39. doi: 10.1091/mbc.E14-07-1197. Epub 2015 Mar 4.
    View in: PubMed
  10. Steininger RJ 3rd, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ.  On comparing heterogeneity across biomarkers. Cytometry part A (special issue on systems microscopy). 2014 Nov 25. doi: 10.1002/cyto.a.22599.
    View in: PubMed
  11. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ.  GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2014 Nov 17. doi: 10.1038/nchembio.1690.
    View in: PubMed
  12. Agi E, Langen M, Altschuler SJ, Wu LF, Zimmermann T, Hiesinger PR. The Evolution and Development of Neural Superposition. J Neurogenet. 2014 Jul 8; 1-17.
    View in: PubMed
  13. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 May 29; 11(6):602.
    View in: PubMed
  14. Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler SJ. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014; (85).
    View in: PubMed
  15. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16.
    View in: PubMed
  16. Zhang ER, Wu LF, Altschuler SJ. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42.
    View in: PubMed
  17. Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F. The Zoo of Solitons for Curve Shortening in n. Nonlinearity. 2013; 26(5):1189-1226. Videos.
  18. Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu LF. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jul; 9(7):634-5.
    View in: PubMed
  19. Rajaram S, Pavie B, Wu LF, Altschuler SJ. PhenoRipper: software for rapidly profiling microscopy images.  Nat Methods. 2012 Jul; 9(7):635-7.
    View in: PubMed
  20. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83.
    View in: PubMed
  21. Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15.
    View in: PubMed
  22. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88.
    View in: PubMed
  23. Jilkine A, Angenent SB, Wu LF, Altschuler SJ. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Computational Biol. 2011 Nov; 7(11):e1002271.
    View in: PubMed
  24. Altschuler SJ, Wu LF. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63.
    View in: PubMed
  25. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369.
    View in: PubMed
  26. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. On identifying information from image-based spatial polarity phenotypes in neutrophils. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 1; 14-17:1029-1032.
    View in: PubMed
  27. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 2; 187(3):375-84.
    View in: PubMed
  28. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65.
    View in: PubMed
  29. Artyukhin AB, Wu LF, Altschuler SJ. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21.
    View in: PubMed
  30. Slack MD, Martinez ED, Wu LF, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19306-11.
    View in: PubMed
  31. Altschuler SJ, Angenent SB, Wang Y, Wu LF. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9.
    View in: PubMed
  32. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221.
    View in: PubMed
  33. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22.
    View in: PubMed
  34. Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53.
    View in: PubMed
  35. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003.
    View in: PubMed
  36. Loo, L.H., Wu, L., Altschuler, S.J., 2006; 251-54. Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
  37. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30.
    View in: PubMed
  38. Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6.
    View in: PubMed
  39. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8.
    View in: PubMed
  40. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33.
    View in: PubMed
  41. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5.
    View in: PubMed
  42. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65.
    View in: PubMed
  43. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7.
    View in: PubMed
  44. Acero, A., Altschuler S.J., Wu L.F. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. Proceedings of the ICSLP. 2000.
  45. Altschuler, S.J., Wu, L.F. On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
  46. Ridgeway, G., Altschuler, S.J. Clustering finite discrete markov chains. Proceedings of the Section on Physical and Engineering Sciences. 1998; 228-229.
  47. Altschuler, S.J., Kim, W. Proceedings of the ICSR5. Generating Signal Processing Software. 1998.
  48. Altschuler, S.J., Angenet, S., Giga, Y. Mean curvature flow through singularities for surfaces of rotation. Journal of Geometric Analysis. 1995; 5(3):293-358.
  49. Altschuler, S.J. A geometric heat flow for one-forms on three dimensional manifolds. Illinois Journal of Mathematics. 1995; 39(1):98-118.
  50. Altschuler, S.J., Wu, L.F. Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
  51. Wu, L.F. The Ricci Flow on complete R2. Comm. in Analysis and Geometry. 1993; 1:439-472.
  52. Wu, L.F. A new result for the porous medium equation on R2 derived from the Ricci flow. Bulletin of the American Mathematical Society. 1993; 28:90-94.
  53. Altschuler, S.J., Wu, L.F. Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
  54. Altschuler, S.J., Grayson, M. Shortening space curves and flow through singularities. Journal of Differential Geometry. 1992; 35(2):283-298.
  55. Altschuler, S.J. Singularities for the curve shortening flow for space curves. Journal of Differential Geometry. 1991; 34(2):491-514.
  56. Wu, L.F. The Ricci Flow on 2-orbifolds with positive curvature. Journal of Differential Geometry. 1991; 33:575-596.
  57. Chow, B., Wu, L.F. The Ricci Flow on compact 2-orbifolds with curvature negative somewhere. Communications on Pure and Applied Mathematics. 1991; 44:275-286.